Description
KPV is a tripeptide corresponding to the C-terminal sequence (residues 11–13) of alpha-melanocyte-stimulating hormone (α-MSH). OxygenLab supplies KPV as a lyophilized powder (10 mg per vial), third-party tested with a batch certificate of analysis.
KPV Specifications
| Compound | KPV |
|---|---|
| Sequence / structure | Lys-Pro-Val (tripeptide) |
| Molecular formula | C16H30N4O4 |
| Molecular weight | 342.4 g/mol |
| CAS number | 67727-97-3 |
| Form | Lyophilized powder |
| Amount per vial | 10 mg |
| Purity | Verified per batch by HPLC and MS (see COA) |
Formula, molecular weight and CAS number per PubChem.
Research Overview
KPV is studied in inflammation-signalling research, including cell-culture models of epithelial and keratinocyte stress and animal models of intestinal barrier function.
Recent work has also used KPV to explore peptide delivery systems such as hydrogels and transdermal methods.
Selected Research References
- A KPV-binding double-network hydrogel restores gut mucosal barrier in an inflamed colon, Acta Biomater, 2022.
- Lysine-Proline-Valine peptide mitigates fine dust-induced keratinocyte apoptosis and inflammation, Tissue Cell, 2025.
KPV: Research Background
α-Melanocyte-stimulating hormone (α-MSH) is a 13-residue peptide. KPV corresponds to its last three residues (positions 11–13) and is studied as a standalone tripeptide.
Published work describes KPV reducing NF-κB and MAPK inflammatory signalling in epithelial and immune cell models. Studies in intestinal epithelial cells reported uptake through the PepT1 di/tripeptide transporter, and several reports suggest some of its activity does not depend on melanocortin receptor 1, unlike the parent hormone.
More recent research uses KPV as a model payload for delivery systems such as hydrogels, nanoparticles and transdermal formulations.
What the KPV COA Confirms
Each batch is tested by an independent laboratory. HPLC reports purity as the main peak’s share of total peak area, and mass spectrometry confirms identity against the expected molecular weight of 342.4 g/mol. Batch-specific reports are published on our COAs page; match the lot number on your vial to the report before use in an experiment.
Related Research Compounds
Laboratories working with KPV often also reference: BPC-157, GHK-Cu, KLOW Blend.
More Questions About KPV
Which part of α-MSH is KPV?
Residues 11–13: Lys-Pro-Val, the C-terminal end of the 13-residue hormone.
How does KPV enter cells in research models?
Studies in intestinal epithelial cells reported transport by PepT1, the di- and tripeptide transporter.
Storage and Handling
- Store lyophilized powder at -20°C for long-term storage, protected from light and moisture.
- Short-term storage at 2–8°C is acceptable for unopened vials.
- Allow the vial to reach room temperature before opening to limit moisture uptake.
- Prepare solutions according to your laboratory protocol and record batch and lot numbers.
Frequently Asked Questions
How is the purity of KPV verified?
Each batch is tested by an independent third-party laboratory for identity and purity (HPLC and mass spectrometry). The certificate of analysis is published on our COAs page.
How should lyophilized KPV be stored?
Store unopened vials at -20°C, protected from light and moisture. Short-term storage at 2–8°C is acceptable.
Is KPV intended for human use?
No. KPV is sold strictly for laboratory research use and is not for human or animal consumption.
Related Research Guides
- How to read a peptide certificate of analysis
- What HPLC purity means for research peptides
- How to store lyophilized peptides
Research use only. This product is supplied for in-vitro laboratory research and analytical use only. It is not for human or animal use, and not intended to diagnose, treat, cure or prevent any disease. See our Legal & Compliance policy.
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