MOTS-c 10mg

Description

MOTS-c is a 16-amino-acid peptide encoded within the mitochondrial 12S rRNA gene, part of the family of mitochondrial-derived peptides. OxygenLab supplies MOTS-c as a lyophilized powder (10 mg per vial), third-party tested; published certificates are on our COA page.

MOTS-c Specifications

Formula, molecular weight and CAS number per PubChem.

Research Overview

MOTS-c is studied in metabolic and mitochondrial research, including AMPK signalling and insulin-sensitivity pathways in rodent models.

The 2015 Cell Metabolism paper that first characterised it is the most-cited starting point for this research area.

Selected Research References

• The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance, Cell Metab, 2015.
• MOTS-c: A promising mitochondrial-derived peptide for therapeutic exploitation, Front Endocrinol, 2023.

MOTS-c: Research Background

MOTS-c was first described in 2015 by researchers at the University of Southern California. It is encoded by a short open reading frame inside the mitochondrial 12S rRNA gene, making it one of a small family of mitochondrial-derived peptides alongside humanin.

Mouse studies linked MOTS-c to the folate cycle and AMPK activation, with skeletal muscle identified as a major target tissue. A 2018 study reported that MOTS-c moves from the cytoplasm to the nucleus under metabolic stress and influences nuclear gene expression, an example of mitochondria-to-nucleus (retrograde) signalling.

These findings make MOTS-c a reference compound in research on how mitochondria communicate with the rest of the cell.

What the MOTS-c COA Confirms

OxygenLab products are tested by independent third-party laboratories. HPLC reports purity as the main peak’s share of total peak area, and mass spectrometry confirms identity against the expected molecular weight of 2174.6 g/mol. Published certificates are on our COA page, and others are available on request; match the lot number on your vial to the report before use in an experiment.

Related Research Compounds

Laboratories working with MOTS-c often also reference: NAD+, Glutathione.

More Questions About MOTS-c

Where is MOTS-c encoded?

In the mitochondrial genome, within the 12S rRNA gene, rather than in nuclear DNA.

What is a mitochondrial-derived peptide?

A peptide encoded by mitochondrial DNA. MOTS-c and humanin are the best-studied examples.

Storage and Handling

• Store lyophilized powder at -20°C for long-term storage, protected from light and moisture.
• Short-term storage at 2–8°C is acceptable for unopened vials.
• Allow the vial to reach room temperature before opening to limit moisture uptake.
• Record batch and lot numbers for every preparation.

Frequently Asked Questions

How is the purity of MOTS-c verified?

OxygenLab products are tested by independent third-party laboratories for identity and purity (HPLC and mass spectrometry). A certificate for this product is available on request; contact us. Published certificates are on our COA page.

How should lyophilized MOTS-c be stored?

Store unopened vials at -20°C, protected from light and moisture. Short-term storage at 2–8°C is acceptable.

Is MOTS-c intended for human use?

No. MOTS-c is sold strictly for laboratory research use and is not for human or animal consumption.

Related Research Guides

• How to read a peptide certificate of analysis
• What HPLC purity means for research peptides
• How to store lyophilized peptides

Research use only. This product is supplied for in-vitro laboratory research and analytical use only. It is not for human or animal use, and not intended to diagnose, treat, cure or prevent any disease. See our Legal & Compliance policy.